Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
17 "Eun Jung Lee"
Filter
Filter
Article category
Keywords
Publication year
Authors
Brief Case Reports
Mucosal Schwann Cell Hamartoma in Colorectal Mucosa: A Rare Benign Lesion That Resembles Gastrointestinal Neuroma
Jiheun Han, Yosep Chong, Tae-Jung Kim, Eun Jung Lee, Chang Suk Kang
J Pathol Transl Med. 2017;51(2):187-189.   Published online August 25, 2016
DOI: https://doi.org/10.4132/jptm.2016.07.02
  • 9,682 View
  • 197 Download
  • 5 Web of Science
  • 11 Crossref
PDF

Citations

Citations to this article as recorded by  
  • Schwann Cell Hamartoma Presenting as a Colonic Polyp: A Rare Case Report With a Literature Review
    Faryal Altaf, Nismat Javed, Haider Ghazanfar, Anil Dev
    Cureus.2024;[Epub]     CrossRef
  • Multiple non-polypoid mucosal Schwann cell hamartomas presenting as edematous and submucosal tumor-like lesions: a case report
    Takeshi Okamoto, Takaaki Yoshimoto, Katsuyuki Fukuda
    BMC Gastroenterology.2021;[Epub]     CrossRef
  • Mucosal schwann cell hamartoma of the gall bladder
    Kanika Sharma, AnjanKumar Dhua, Prabudh Goel, Vishesh Jain, DevendraKumar Yadav, Prashant Ramteke
    Journal of Indian Association of Pediatric Surgeons.2021; 26(3): 182.     CrossRef
  • Mucosal Schwann Cell Hamartoma in sigmoid colon – A rare case report and review of literature
    Xiuyan Feng, Hongzhi Xu, Nestor Dela Cruz
    Human Pathology: Case Reports.2020; 19: 200337.     CrossRef
  • Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma
    Patrice Grech, John B Schofield
    Histopathology.2020; 76(3): 342.     CrossRef
  • Mucosal Schwann cell hamartoma of the gastroesophageal junction: A series of 6 cases and comparison with colorectal counterpart
    Yuan Li, Pouneh Beizai, John W. Russell, Lindsey Westbrook, Arash Nowain, Hanlin L. Wang
    Annals of Diagnostic Pathology.2020; 47: 151531.     CrossRef
  • Mucosal Schwann Cell Hamartoma Presenting as Diffuse Fine Nodularities
    Han Beol Jang, Jong Ok Kim, Sang-Bum Kang
    The Korean Journal of Gastroenterology.2020; 76(3): 171.     CrossRef
  • A case of Schwann cell hamartoma of the tongue
    Saya TAKIKAWA, Shigeo TANAKA, Masamichi KOMIYA, Masaaki SUEMITSU, Tadahiko UTSUNOMIYA, Kayo KUYAMA
    Japanese Journal of Oral and Maxillofacial Surgery.2020; 66(12): 601.     CrossRef
  • Hamartoma de células de Schwann mucoso: revisión de una entidad descrita recientemente
    Francisco García-Molina, José Antonio Ruíz-Macia, Joaquin Sola
    Revista Española de Patología.2018; 51(1): 49.     CrossRef
  • Neural and neurogenic tumours of the gastroenteropancreaticobiliary tract
    Aoife J McCarthy, Dipti M Karamchandani, Runjan Chetty
    Journal of Clinical Pathology.2018; 71(7): 565.     CrossRef
  • Case of colonic mucosal Schwann cell hamartoma and review of literature on unusual colonic polyps
    JayaKrishna Chintanaboina, Kofi Clarke
    BMJ Case Reports.2018; : bcr-2018-224931.     CrossRef
Necrotizing Sarcoid Granulomatosis: Possibly Veiled Disease in Endemic Area of Mycobacterial Infection
Yosep Chong, Eun Jung Lee, Chang Suk Kang, Tae-Jung Kim, Jung Sup Song, Hyosup Shim
J Pathol Transl Med. 2015;49(4):346-350.   Published online June 1, 2015
DOI: https://doi.org/10.4132/jptm.2015.04.17
  • 7,423 View
  • 74 Download
  • 11 Web of Science
  • 11 Crossref
PDF

Citations

Citations to this article as recorded by  
  • Sarcoidosis With Skeletal Involvement Masquerading as Metastatic Malignancy
    Arthur M Samia, Stephanie Fabara Pino, Liang Sun
    Cureus.2023;[Epub]     CrossRef
  • Necrotic sarcoid granulomatosis – a late stage of nodular sarcoidosis or an independent disease? Analysis of a clinical case
    E. A. Galushko, E. V. Pozhidaev, S. G. Radenska-Lopovok, A. V. Gordeev, M. V. Shaligina, A. V. Alekseeva, M. A. Sedelnikova
    Rheumatology Science and Practice.2023; 61(5): 624.     CrossRef
  • Incidental Lung Cavity in the Heartland
    Biplab K. Saha, Om Dawani, Woon H Chong, Alyssa Bonnier
    The American Journal of the Medical Sciences.2022; 363(2): 191.     CrossRef
  • A rare presentation of necrotizing sarcoidosis
    Nirali Sheth, Umaima Dhamrah, Branden Ireifej, David Song, Penpa Bhuti, Jagbir Singh, Henry Fan, Sibghatallah Ummar, Vikash Jaiswal, Nishan Babu Pokhrel
    Respirology Case Reports.2022;[Epub]     CrossRef
  • Necrotizing Granulomatous Dacryoadenitis With Non-Necrotizing Granulomatous Scar Hypertrophy: Two Histological Variants of Sarcoidosis in the Same Patient
    Erin E. Godbout, M. Kristina Subik, Tal J. Rubinstein
    Ophthalmic Plastic & Reconstructive Surgery.2021; 37(1): e30.     CrossRef
  • Necrotizing sarcoid granulomatosis simulating pulmonary malignancy
    Jun Hyeok Kim, Bo Da Nam, Jung Hwa Hwang, Dong Won Kim, Ki-Up Kim, Young Woo Park
    Medicine.2021; 100(49): e28208.     CrossRef
  • Necrotizing Sarcoid Granulomatosis: A Disease Not to be Forgotten
    A. I. Parejo-Morón, M. L. Tornero-Divieso, M. R. Férnandez-Díaz, L. Muñoz-Medina, O. Preda, N. Ortego-Centeno
    Case Reports in Medicine.2020; 2020: 1.     CrossRef
  • Clinical Reasoning: A woman with monocular vision loss
    Husain Danish, Tatiana Bakaeva, Isaac Solomon, Sashank Prasad
    Neurology.2020;[Epub]     CrossRef
  • Cavity forms of thoracic sarcoidosis (literature review, clinical and radiological observations)
    A. V. Lenshin, A. V. Il'in, Yu. M. Perelman
    PULMONOLOGIYA.2020; 30(6): 831.     CrossRef
  • Thoracic sarcoidosis versus tuberculosis: Need for a multi-disciplinary approach
    Agrima Mian, Animesh Ray
    Indian Journal of Radiology and Imaging.2018; 28(02): 267.     CrossRef
  • Necrotizing sarcoid granulomatosis with clinical presentations of recurrent acute abdomen. Case report and literature review
    V. I. Vasilyev, S. G. Palshina, B. D. Chaltsev, S. G. Radenska-Lopovok, T. N. Safonova
    Terapevticheskii arkhiv.2017; 89(11): 60.     CrossRef
Fine Needle Aspiration Cytology of Warthin-like Papillary Thyroid Carcinoma: A Brief Case Report
Yosep Chong, Sungwook Suh, Tae-Jung Kim, Eun Jung Lee
Korean J Pathol. 2014;48(2):170-173.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.170
  • 7,547 View
  • 38 Download
  • 10 Crossref
PDF

Citations

Citations to this article as recorded by  
  • Warthin-like variant of papillary thyroid carcinoma with lymph node metastases: a case report and review of the literature
    Andrii Hryshchyshyn, Andrii Bahrii, Pavlina Botsun, Volodymyr Chuba
    Journal of Medical Case Reports.2024;[Epub]     CrossRef
  • The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases
    Xing Zhao, Yijia Zhang, Pengyu Hao, Mingzhen Zhao, Xingbin Shen
    Oncologie.2023; 25(5): 581.     CrossRef
  • Solid papillary thyroid carcinoma with Hashimoto’s thyroiditis: description of a further case with challenging cytological features
    Franco Fulciniti, Jessica Barizzi, Pierpaolo Trimboli, Luca Giovanella
    BMJ Case Reports.2019; 12(1): e226153.     CrossRef
  • Preoperative Cytologic Diagnosis of Warthin-like Variant of Papillary Thyroid Carcinoma
    Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo
    Journal of Pathology and Translational Medicine.2018; 52(2): 105.     CrossRef
  • Warthin like papillary carcinoma - A rare variant of papillary carcinoma thyroid
    Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat Bashir
    Human Pathology: Case Reports.2018; 13: 21.     CrossRef
  • Cytological features of warthin‐like papillary thyroid carcinoma: A case report with review of previous cytology cases
    Archana George Vallonthaiel, Shipra Agarwal, Deepali Jain, Rajni Yadav, Nishikant A. Damle
    Diagnostic Cytopathology.2017; 45(9): 837.     CrossRef
  • Comparison of EASYPREP® and SurePath® in thyroid fine‐needle aspiration
    Yosep Chong, Ki Hyun Baek, Jee Young Kim, Tae‐Jung Kim, Eun Jung Lee, Chang Suk Kang
    Diagnostic Cytopathology.2016; 44(4): 283.     CrossRef
  • Ultrasonographic features and clinical characteristics of Warthin-like variant of papillary thyroid carcinoma
    Ga Ram Kim, Jung Hee Shin, Soo Yeon Hahn, Eun Young Ko, Young Lyun Oh
    Endocrine Journal.2016; 63(4): 329.     CrossRef
  • Warthin-Like Papillary Thyroid Carcinoma Associated with Lymphadenopathy and Hashimoto’s Thyroiditis
    Karla Judith González-Colunga, Abelardo Loya-Solis, Luis Ángel Ceceñas-Falcón, Oralia Barboza-Quintana, René Rodríguez-Gutiérrez
    Case Reports in Endocrinology.2015; 2015: 1.     CrossRef
  • Tumeur Warthin-like de la thyroïde : à propos d’un cas
    W. Rekik, A. Khadhar, A. Zehani, H. Azouz, I. Chelly, T. Ben Ghachem, A. Sellem, M. Tounsi, H. Ben Mahjouba, S. Haouet, N. Kchir
    Journal Africain du Cancer / African Journal of Cancer.2015; 7(4): 247.     CrossRef
Esophageal Squamous Cell Carcinoma In Situ Overlying Leiomyoma Mimicking Invasive Cancer: A Brief Case Report
Woo Jin Oh, Eun Jung Lee, Youn Soo Lee, Tae-Jung Kim
Korean J Pathol. 2014;48(2):162-163.   Published online April 28, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.162
  • 5,825 View
  • 36 Download
  • 2 Crossref
PDF

Citations

Citations to this article as recorded by  
  • Esophageal squamous cell carcinoma or high-grade dysplasia overlying leiomyoma, rare but not to be neglected
    Changyuan Guo, Dan Liu, Yong Liu, Lei Guo, Lulu Rong, Guiqi Wang, Ning Lu, Liyan Xue
    Esophagus.2021; 18(1): 125.     CrossRef
  • Esophageal leiomyoma and simultaneous overlying squamous cell carcinoma: a case report and review of the literature
    Saadat Mehrabi, Mohammad Javad Yavari Barhaghtalab, Safoora Hejazinia, Hossein Saedi
    BMC Surgery.2021;[Epub]     CrossRef
Case Report
Primary Malignant Melanoma of the Urinary Bladder: A Case Report.
Sung Hak Lee, Eun Deok Chang, Eun Jung Lee, Chang Suk Kang
Korean J Pathol. 2010;44(2):216-219.
DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.2.216
  • 3,387 View
  • 39 Download
AbstractAbstract PDF
Primary malignant melanoma in the bladder is very rare, with only 18 cases having been currently reported. A 65-year-old male patient presented with a 5-month history of gross hematuria. On ultrasonography, an 8.1 x 6.1 cm mass was revealed on the bladder wall. A partial cystectomy was performed. Microscopically, the tumor was composed of atypical, pigmented melanocytes that were positive for S-100 protein and they were negative for human melanoma black-45. Although he underwent supportive therapy, an 8.7 x 5.9 cm mass occupying the prevesical space was noted on a follow-up computed tomography scan 4 months later. Two nodules of the left lower lung and multiple enlarged lymph nodes in the left external iliac chain were also revealed. The patient declined any further treatment. The histogenesis of primary bladder melanoma is uncertain, but an origin from neural crest cells has been proposed. The prognosis for patients with this tumor is still poor despite the availability of several therapeutic options.
Short Case Report
Pneumocystis jirovecii Pneumonia Accompanied with Fat Embolism: A Case Report.
Sung Hak Lee, Ok Ran Shin, Eun Jung Lee, Kyo Young Lee
Korean J Pathol. 2009;43(4):355-357.
DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.4.355
  • 2,578 View
  • 17 Download
AbstractAbstract PDF
Pneumocystis jirovecii is an atypical fungus that causes severe pneumonia in immune compromised patients. While Pneumocystis jirovecii pneumonia (PCP) is more commonly diagnosed in individuals who have HIV infection, it can occur in individuals with other forms of immunosuppression. Fat embolism most commonly develops after orthopedic injuries, but it has also been reported after other forms of trauma such as severe burns, closed-chest cardiac massage, and liposuction. Overlap in the clinical presentation of these diseases has not yet been reported. We report here on a case of PCP with fat embolism in 52-year-old female patient who had no obvious risk factors for HIV infection. Even if risk factors for HIV or other forms of immunosuppression are not present, PCP can also be seen in patients who present with fat embolism, and the clinical presentation of both conditions can overlap.
Case Reports
Primary Teratocarcinoma of the Pineal Gland: A case report.
Kyoung Mee Kim, Eun Jung Lee, Ki Wha Yang, Anhi Lee, Sang In Shim, Sun Moo Kim
Korean J Pathol. 1995;29(4):527-529.
  • 1,828 View
  • 19 Download
AbstractAbstract PDF
Teratocarcinoma is a form of mixed germ cell tumor composed of a mixture of teratoma and embryonal carcinoma. It is rarely found in the brain, but when present it is most commonly found in the pineal region. We investigated a case of primary teratocarcinoma in the pineal region. The patient was a 10 year old boy who had suffered from a bitemporal headache for one month. Brain CT and MRI revealed a rather well defined ovoid heterogenous mass in the pineal gland region, measuring 4.3 x 3.8 x 3.0 cm in size. Microscopically the tumor contained areas of immature teratoma and embryonal carcinoma. Immunohistochemical staining revealed positive reactions for cytokeratin, epithelial membrane antigen, carcinoembryonic antigen, and alpha-fetoprotein in the embryonal carcinoma component.
Normoblasts and Lymphocytes Carry the Fused Bcr-Abl Gene in Chronic Myelogenous Leukemia: Two Color Fluorescence in Situ Hybridization(FISH) Analysis on the Blood Smears.
Chang Suk Kang, Eun Jung Lee, Won bae Lee, Yong goo Kim, Kyung Ja Han, Kyung Soo Lee, Sang In Shim
Korean J Pathol. 1998;32(1):58-62.
  • 1,510 View
  • 12 Download
AbstractAbstract PDF
We performed dual color fluorescence in situ hybridization (FISH) for the bcr/abl fusion in CML using the peripheral blood smears without destruction of cell morphology to determine the bcr/abl fusion. Two patients of CML, one patient in accelerated phase and one patient in chronic phase, were selected. The blood smears were fixed in absolute methanol. FISH was performed with the Mbcr/abl translocation DNA probe mixture and the slides were stained with Wright's stain after FISH. The blood smears of both cases revealed distinct signals without destruction of cellular morphology. The normoblasts and lymphocytes revealed beautiful fused bcr/abl signals as well as granulocytes in both cases. The results provide a novel finding that the normoblasts and lymphocytes in CML are also neoplastic clonal cells which has not been demonstrated with a single-cell approach before.
Primary Malignant Melanoma of the Esophagus: A case report.
Lee So Maeng, Kyoung Mee Kim, Eun Jung Lee, Anhi Lee, Sang In Shim
Korean J Pathol. 1998;32(9):694-696.
  • 1,481 View
  • 10 Download
AbstractAbstract
This report presents an unusual case of primary malignant melanoma in the midesophagus. The patient was a 36-year-old woman presenting with dysphagia and odynophagia. The resected esophagus and proximal stomach showed a dark purple large polypoid mass, measuring 6.0 3.3 2.0 cm, with a diffuse tan pigmentation of surrounding mucosa in the mid-esophagus and two small daughter nodules, up to 1.2 0.3 cm, in the lower esophagus near the gastro-esophageal junction. A microscopic examination revealed a malignant melanoma of epithelioid cell type confined to mucosa and submucosa with a diffuse melanosis. Cytoplasmic immunoreactivity for HMB 45 and S-100 protein were noted. An electron microscopic examination revealed large, loosely cohesive variable shaped cells with a few cytoplasmic premelanosomes.
Papillary Adenocarcinoma of Nonpigmented Ciliary Epithelium of the Eye.
Hyun Joo Choi, Yeong Jin Choi, Youn Soo Lee, Eun Jung Lee, Seok Jin Kang, Byung Kee Kim, Sang In Shim
Korean J Pathol. 1998;32(12):1104-1107.
  • 1,536 View
  • 10 Download
AbstractAbstract
Adenocarcinoma of the ciliary epithelium is a rare tumor, usually occuring in elderly patients who have a history of severe ocular trauma or chronic inflammation. We report an adenocarcinoma of the nonpigmented ciliary epithelium found within the phthisical globe of a 36-year-old female whose eye had been loss of vision since infancy. The mass, measured 4.0 x 4.0 cm, was relatively limited by sclera but had invasion to posterior portion. Histologically, the tumor was a compact mass which consisted of tubular and papillary structures with foci of the pleomorphic area. Strands of cells and individual cells were invested with thick basement membrane that have positivity for periodic acid-Schiff stain. Immunohistochemical staining showed strong reactivity for cytokeratin and epithelial membrane antigen, and focal for neuron-specific enolase and S-100 protein.
Original Article
AgNOR Counts in S-phase Human Cells.
Seung Il Kim, Eun Jung Lee
Korean J Pathol. 1999;33(2):103-107.
  • 1,380 View
  • 11 Download
AbstractAbstract
The nucleolus of human cell is a morphologically well recognizable nuclear organelle and the argyrophilic NORs (AgNORs) are nucleic acid-argyrophilic nonhistone protein complex in the nucleoli and the silver staining allows their identification and enumeration at the light microscopic level. The AgNOR counts are in parallel with mitotic activity and vary in different phase of cell cycle. It has been reported that human cells have one AgNOR during interphase and S-phase. However, the correlation between the number of AgNORs and S-phase markers is still controversial and they have never been studied simultaneously. In this study, AgNOR and PCNA were stained simultaneously to find out the relationship of AgNOR counts with cell cycle (S-phase) in human palatine tonsil, gastric carcinoma, liver and brain tissues. S-phase cells (PCNA-positive) were found predominantly in lymphoid follicles in palatine tonsil but gastric carcinoma showed diffuse immunoreactivity for PCNA. The AgNOR counts varied according to the type and locus of tissue. More than one AgNOR were identified in S-phase cells and some of hepatocytes and neurons in the brain which were not in S-phase contained two or more AgNORs. The above results suggest that the number of AgNOR is a characteristic feature of each type of cells and can be more than one even in S-phase.
Case Report
Chromophobe Renal Cell Carcinoma.
Yeong Jin Choi, Tae Kon Hwang, Youn Soo Lee, Eun Jung Lee, Seok Jin Kang, Byung Kee Kim, Sang In Shim
Korean J Pathol. 1999;33(4):259-266.
  • 1,614 View
  • 17 Download
AbstractAbstract PDF
We report 13 chromophobe renal cell carcinomas (10.8%) observed among 120 renal cell carcinomas in adults. The average age was 53 (range: 34-72) years old, and 6 were males and 7 females. The mean tumor size was 10 (range: 5-17) cm, mean nuclear grade 2.4, and mean Robson's stage was 1.9. There were two distinct histologic variants; typical variant (n=9) and eosinophilic variant (n=4). Both of them showed typical light microscopic features and positive reaction with Hale's colloidal iron and carbonic anhydrase II, a marker protein of intercalated cells of renal collecting ducts. A strong positive immunoreactivity for epithelial membrane antigen was noted in the cytoplasm in 12 of 13 tumors. Numerous microvesicles, 180~440 nm in diameter, were identified ultrastructurally. DNA aneuploidy was found in 3 out of 10 cases. Neither local recurrence nor metastasis have been identified during the following period of 4~144 (mean 48) months.
Original Articles
Expression of CD44 Splicing Variants v4/5 and v6 in Gastric Adenocarcinoma and Its Relationship with Prognostic Factors.
Lee So Maeng, Hae Kyung Lee, Byung Kee Kim, Eun Jung Lee
Korean J Pathol. 2000;34(2):119-124.
  • 1,449 View
  • 11 Download
AbstractAbstract PDF
CD44, an integral membrane glycoprotein expressed by many cell types, serves as the principal transmembrane hyaluronate receptor and may be a determinant of metastatic and invasive behavior in carcinomas. This study was performed to investigate the relationship between CD44 splicing variants v4/5 and v6 expression and histopathologic prognostic factors (depth of tumor invasion, histologic classification, vascular and lymphatic invasion, and lymph node metastasis) in 107 gastric adenocarcinomas. In 107 cases of gastric carcinoma, the immunohistochemical stainining for CD44 v4/5 and CD44 v6 gave the following results. CD44 v4/5 was expressed in 40.2% and CD44 v6 in 67.3% of gastric carcinomas. The expression of CD44 v4/5 was correlated with histologic classification by Lauren (p<0.05), lymphatic invasion (p<0.05), and lymph node metastasis (p<0.004). In contrast, expression of CD44 v6 had no impact on prognostic markers. This study suggests the role of CD44 v4/5 in invasion, metastasis, and its prognostic significance in gastric adenocarcinoma.
E-cadherin Expression in Distinguishing Ductal and Lobular Carcinomas of the Breast.
Eun Deok Chang, An Hi Lee, Eun Jung Lee, Seok Jin Kang, Chang Suk Kang
Korean J Pathol. 2002;36(5):323-327.
  • 1,953 View
  • 22 Download
AbstractAbstract PDF
BACKGROUND
Most breast carcinomas are easily categorized as ductal or lobular. However, in some cases the distinction can be difficult since some tumors may have intermediate features of these two. Prior studies suggest that E-cadherin is useful to classify tumors as ductal or lobular, as it is lost in lobular but not in ductal carcinomas.
METHODS
We studied the histologic features and E-cadherin expression by immunohistochemistry in 57 cases of breast carcinomas, which were divided into three groups based on histology. Group 1 included 4 cases of infiltrating lobular carcinoma (IFL) and 1 case of lobular carcinoma in situ (LCIS) (n=5). Group 2 included infiltrating ductal carcinoma (IFD) with some features of IFL (n=48). Group 3 included a solid type of intraductal carcinoma (DCIS) (n=4). E-cadherin staining was scored as negative or positive.
RESULTS
All 5 cases from group 1 were E-cadherin negative, and all 4 DCIS cases were positive. Only 2 (0.04%) of the 48 cases from group 2 were E-cadherin negative.
CONCLUSIONS
Our findings suggest that the majority of cases with morphologically IFD with some IFL features are ductal. E-cadherin immunostaining is of value in helping to characterize breast carcinomas with indeterminate morphologic features.
Expression of Survivin According to Malignant Progression of Breast Lesions.
Hyun Joo Choi, Ji Han Jung, Chan Kwon Jung, Jinyoung Yoo, Eun Jung Lee, Chang Suk Kang, Seok Jin Kang, Kyo Young Lee
Korean J Pathol. 2007;41(4):238-243.
  • 1,684 View
  • 14 Download
AbstractAbstract PDF
BACKGROUND
The aim of this study was to examine the survivin expression pattern in benign lesions, atypical ductal hyperplasias (ADH), ductal carcinomas in situ (DCIS) and in invasive carcinomas of the breast and to evaluate the effect of expression of this marker on the malignant progression of breast cancers. In addition, the relationship between the expression of the marker and the clinicopathological characteristics for invasive carcinomas were investigated.
METHODS
Immunohistochemical staining using a tissue microarray method for survivin was performed for 103 benign lesions, 30 ADHs, 26 DCISs and 116 invasive carcinomas.
RESULTS
The expression of cytoplasmic survivin was higher for invasive carcinomas than for ADHs and DCISs (p<0.05). For breast invasive carcinomas, expression of cytoplasmic survivin significantly correlated with tumor size, lymph node metastasis and stage (p<0.05).
CONCLUSIONS
These results suggest that overexpression of cytoplasmic survivin may be involved in the development of the late stage of breast malignancy, especially invasiveness. In breast invasive carcinomas, expression of survivin may be a useful indicator for the evaluation of patient prognosis.

J Pathol Transl Med : Journal of Pathology and Translational Medicine